Gold(I)-Catalyzed Synthesis of 3-Sulfenyl Pyrroles and Indoles by a Regioselective Annulation of Alkynyl Thioethers

The combination of nucleophilic nitrenoids and ?-acid catalysis has emerged as a powerful tool in heterocycle synthesis. Accessing more varied heterocycle-substitution patterns by maintaining the same reaction pathways across different alkynes remains challenge. Here we show that Au(I) isoxazole-based with alkynyl thioethers provides controlled access to (3 + 2) annulation regioselective addition ? sulfenyl group. isoxazole-containing delivers sulfenylated pyrroles indoles single regioisomers bearing useful functional groups structural variety.